美国卫生与公共服务部第13次有关致癌物的报告已添加了四种物质，该报告是基于科学的文件，该文件识别出被认为是对居住在美国患者的癌症危害的化学，生物和物理药物。新报告包括243个列表。
用于制造橡胶化学物质，农药和染料的正苯胺已被重新评估，现在被列为已知的人类致癌物。已经添加了三种物质是人类致癌物。其中包括1-溴丙烷，用作清洁溶剂和喷雾粘合剂；Cumene，用于制造苯酚和丙酮，也可以在燃料产品和烟草烟雾中发现；和木材防腐剂混合物戊二醇。
“Identifying substances in our environment that can make people vulnerable to cancer will help in prevention efforts,” said Linda Birnbaum, Ph.D., director of the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP). “This report provides a valuable resource for health regulatory and research agencies, and it empowers the public with information people can use to reduce exposure to cancer causing substances.”
关于致癌物的报告是NTP为HHS秘书准备的一份国会规定的报告。该报告确定了两类的药物，物质，混合物或暴露剂：已知是人类致癌物，并合理地预期为人类致癌物。新报告可在<http://ntp.niehs.nih.gov/go/roc13>.
A listing in the report indicates a cancer hazard, but does not by itself mean that a substance will cause cancer. Many factors, including the amount and duration of exposure, and an individual’s susceptibility to a substance, can affect whether a person will develop cancer.
一种添加为已知人类致癌物质
自1983年以来，关于致癌物的报告中列出了正苯胺，这是合理地预期是人类致癌物。然而，新的癌症研究导致NTP重新评估和重新分类正苯胺，现在它被添加到已知的人类致癌类别中，基于对人类的研究，表明它会引起尿膀胱癌。Ortho-Toluidine是在其他国家生产的合成化学物质，并由几家高量的公司进口到美国。它主要用于制造橡胶化学物质，农药和染料。它也用于某些消费者和医疗产品中。使用正苯胺时，人们主要通过工作场所，皮肤接触和/或吸入暴露。人们也可以通过烟草烟雾之类的来源在工作场所外面暴露。
新报告中添加了三种物质，这是合理预期的人类致癌物
化学1-溴丙烷是许多商业行业中用作溶剂的无色至浅黄色液体。它被用作光学，电子和金属的清洁剂，以及用于气雾剂涂层胶的溶剂，例如泡沫垫制造中使用的粘合剂。它也用于干洗和溶剂喷雾剂进行飞机维护。某些职业的工人可能比普通人群更容易暴露于1-溴丙烷。尚未确定人类的研究，该研究评估了人类癌症与专门与1-溴丙烷的接触之间的关系。然而，吸入在啮齿动物中接触1-溴丙烷，导致多个器官，包括皮肤，肺部和大肠。
Cumene是一种易燃且挥发性的液体，具有类似汽油的气味。它是煤焦油和石油的自然成分，在烟草烟中发现。它主要用于制造丙酮和苯酚。人们主要通过环境和使用或产生暨的工作场所暴露于暨。它可以在石油产品的排放中找到。吸入对暨烯的吸入导致雄性和雌性小鼠的肺肿瘤，以及雌性小鼠的肝肿瘤。尚未确定人类研究，该研究研究人类癌症与专门与暨烯的接触之间的关系。
Pentachlorophenol and by-products of its synthesis are complex mixtures of chemicals used as wood preservatives. Because virtually everyone who is exposed to pentachlorophenol is also exposed to its synthesis by-products, they were evaluated together. In the United States, pentachlorophenol has been regulated since the 1980s as a restricted-use pesticide. It is used industrially for treating utility poles, wood pilings, fence posts, and lumber or timber for construction. Most exposure has occurred in settings where workers treat lumber or come in contact with treated lumber. People may also be exposed to this mixture from breathing contaminated air or dust, or from contact with contaminated soil. Exposure to this mixture was associated with an increased risk of non-Hodgkin lymphoma in studies in humans. It also caused tumors in the liver and other organs in mice.
The Report on Carcinogens, 13th Edition, is prepared by the National Toxicology Program (NTP). NTP is a federal, interagency program, headquartered at the NIEHS, whose goal is to safeguard the public by identifying substances in the environment that may affect human health. For more information about NTP and its programs, visithttp://ntp.niehs.nih.gov/。
NIEHS supports research to understand the effects of the environment on human health and is part of NIH. For more information on environmental health topics, visithttp://www.niehs.nih.gov。订阅一个或多个NIEHS新闻列表http://www.niehs.nih.gov/news/releases/newslist/index.cfmto stay current on NIEHS news, press releases, grant opportunities, training, events, and publications.
